For example, the Ewing sarcoma LCD is thought to mediate a number of its gene regulatory functions (10, 25, 68, 69), a new genomic approach to probe the regions of the genome that interact with the Ewing sarcoma LCD has revealed other TFs possibly enriched with fusion proteins like EWSR1::FLI1 (70). Here, FLI1 is linked to Ewing sarcoma.