Transcriptome research indicated a notable enrichment of Janus kinase/signal transducer and activator of transcription (JAK/STAT) in the resistant line, aligning with research that illustrates the involvement of JAK/STAT in treatment resistance and the characteristics of cancer stemness (278, 279), proposing that transcriptomics or epitranscriptomics aberrations may be more relevant than genomic alterations in conferring chemoresistance. Here, SOAT1 is linked to cancer.