Using information from the Chinese GBM Genome Atlas (CGGA) and three validation cohorts (TCGA, REMBRANDT, and GSE16011), the research investigated the expression of ADAR3 and its connection to the development of GBM, the prognosis, and RNA editing, with a specific focus on GRIA2Q607R. This evidence concerns the gene ADARB2 and glioblastoma.