For instance, S100A8/A9 and S100A12 can serve as diagnostic biomarkers and are associated with response to anti-tumor necrosis factor (TNF) treatment in systemic JIA patients (7, 8).14-3-3η has been found to have the potential to serve as a new biomarker for polyarticular JIA (9). Here, TNF is linked to polyarticular juvenile idiopathic arthritis.