For example, LRBA (LPS-responsive and beige-like anchor protein) deficiency, CD25 (IL-2Rα) deficiency, and gain-of-function mutations in STAT3 all impair Treg cell development, stability, or suppressive function, and result in syndromes marked by multi-organ autoimmunity (55, 56). Here, IL2RA is linked to Autoimmunity.