When human gastric carcinoma cells were simulated with CXCL12, their morphology changes from elongated to spindle-like fibroblast, along with decreased expression of E-cadherin and increased expression of vimentin, clearly demonstrating the relevance of the CXCL12-CXCR4 signalling axis in the process of EMT (80). This evidence concerns the gene CXCL12 and gastric carcinoma.