Further GO term analysis of genes significantly up-regulated in the Liver ECM group highlighted strong interactions with key liver cancer-related pathways, including the mitogen-activated protein kinase (MAPK) cascade [34], extracellular signal-regulated kinase 1/2 (ERK 1/2) cascade [35], and Wnt signaling [36] (Fig. S3). This evidence concerns the gene WNK2 and liver cancer.