VWM is caused by homozygote or compound heterozygote pathogenic variants in one of five genes (EIF2B1, EIF2B2, EIF2B3, EIF2B4, and EIF2B5), which encode the five subunits of the eukaryotic translation initiation factor 2B holocomplex (EIF2B) (5). This evidence concerns the gene EIF2B2 and leukoencephalopathy with vanishing white matter.