NLRP3 and familial cold autoinflammatory syndrome: NLR family pyrin domain containing 3 (NLRP3)–associated autoinflammatory disease (NLRP3-AID) is an autoinflammatory disease that was once considered to be three distinct clinical entities: neonatal-onset multisystem inflammatory disorder (NOMID)/chronic infantile neurologic, cutaneous, and articular (CINCA); Muckle–Wells syndrome (MWS); and familial cold autoinflammatory syndrome (FCAS) (1).