NLRP3 and familial cold autoinflammatory syndrome: NLR family pyrin domain containing 3 (NLRP3)–associated autoinflammatory disease (NLRP3-AID), formerly known as cryopyrin-associated periodic syndrome, is a group of AIDs comprising neonatal-onset multisystem inflammatory disorder, Muckle–Wells syndrome, and familial cold autoinflammatory syndrome.