There were T-cell–wide increases in the expression of CD62L, a recirculation-promoting T-cell surface protein, that was significant in CD4+ conventional (Tconv; t43.5 = −2.08, P = 0.044) and regulatory T cells (Treg; z = 248, P = 0.009), but not CD8+ T cells (t41.9 = −1.80, P = 0.080), in individuals with migraine compared to healthy controls (Fig. 3A). The gene discussed is CD8A; the disease is migraine disorder.