ENPP2 and migraine disorder: Six proteins were significantly upregulated in migraine with a >1.5 fold change compared to controls and Padj < 0.05 (FAM3C, GOLM1, PSA7, ENPP2, DSG2, TFRC); 3 proteins were significantly downregulated (FGL1, CAH2, AMYP; Fig. 1A).