Unsupervised differential expression analysis of myeloid clusters across migraine phases showed significant upregulation of MMP-9 and the IL-6 receptor family subunit glycoprotein 130 (gp130 or CD130) across all clusters in the interictal period compared to controls, and LIFRα, phospho-MK2, and phospho-STAT3, and decreased phospho-p65 NFκB in select clusters. This evidence concerns the gene STAT3 and migraine disorder.