The main focus of this investigation was to ascertain the potential link between ALDOB level, clinical data, and overall survival (OS) in individuals with ccRCC employing diverse databases, which include The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), the Human Protein Atlas (HPA) and The University of Alabama at Birmingham Cancer data analysis portal (UALCAN). Here, ALDOB is linked to nonpapillary renal cell carcinoma.