Cancers such as cholangiocarcinoma (CHOL), esophageal carcinoma (ESCA), and kidney renal papillary cell carcinomas (KIRP) display down-regulated levels of ALDOB expression, whereas colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) produce higher levels (Figs. 1A–B). The gene discussed is ALDOB; the disease is colon adenocarcinoma.