tissues., Activation of P2X7 receptorsby the endogenous ligand ATP can mediate host immune responses againstexogenous pathogens or endogenous factors,, withimportant involvement in tumor biology., Due to itsroles in diverse aspects of human physiology and pathology, the P2X7 receptor is a rapidly emerging target for the developmentof pharmaceuticals, and radioligands for molecularimaging by positron emission tomography (PET)−,  (Figure A). This evidence concerns the gene P2RX7 and neoplasm.