ALB and hepatocellular carcinoma: Furthermore, the KD value for HCC binding to immobilized heparan sulfate, as probedby SPR, was in a range from 0.8 mM at pH 5.5 to 1.8 mM at pH 6.5.These numbers are in line with the KD valueobtained in this study for interaction with HSA, although the bindingto the hexasaccharide fragment of heparan sulfate is mediated mainlyby the positively charged N-terminal fragment and amino acids aroundHis90 of HCC.