These results underscore the significance of combininga piperazine scaffold with strategically substituted aryl moietiesto develop multitarget-directed ligands (MTDLs), particularly forthe inhibition of MAO-B and BACE-1, offering potential in the treatmentof neurodegenerative conditions such as Alzheimer’s disease.The structure of a potent BACE-1 inhibitor is listed in Table . Here, BACE1 is linked to early-onset autosomal dominant Alzheimer disease.