MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease is a progressive, irreversible,neurodegenerativedisease, i.e., characterized by the presence of amyloid plaques, hyperphosphorylatedtau protein (hyper p-tau), neural damage, etc. β-amyloid precursorprotein cleavage enzyme 1 (BACE-1) inhibition is a promising avenuefor slowing AD progression.