TFF2 and COVID-19: Recent research has shown that both LMWH and UFH interact withthe SARS-CoV-2 spike protein (SP), potentially helping to block viralentry. This interaction suggests thatheparins may serve a dual role in COVID-19 treatment by providingboth anticoagulant and antiviral effects. However, the precise nature of the heparin-SP interaction remainsunclear. To address this, we investigatedthe role of heparin in modulating the interaction between CD147 andSP, aiming to better understand its effects and potential as a preventivetreatment for COVID-19.