Gellai et al. further demonstrated that hyperglycemia-induced O-GlcNAcylation exacerbates renal fibrosis and promotes DKD progression by inhibiting phosphorylation of endothelial nitric oxide synthase (eNOS) and AKT, while upregulating heat shock protein 72 (HSP72) [122]. This evidence concerns the gene NOS3 and renal fibrosis.