Although a meta-analysis shows that vitamin D deficiency may be a risk factor for tuberculosis (Huang et al., 2017), high-dose use of vitamin D cannot effectively accelerate the sputum culture conversion process in the entire trial population, but it is only effective in MDR-TB cases or patients with a specific genotype, such as polymorphisms in the vitamin D receptor gene (Tukvadze et al., 2015; Ganmaa et al., 2017). The gene discussed is VDR; the disease is tuberculosis.