Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by memory loss, synaptic dysfunction, neuroinflammation, mitochondrial deficits, and accumulation of amyloid-beta (Aβ) plaques and hyperphosphorylated tau tangles (Rafiyan and Mojtahedi, 2025). The gene discussed is MAPT; the disease is Alzheimer disease.