CD40LG and Mycoplasmoides infection: Additionally, this study identified that Mycoplasma pneumoniae IgM antibody positivity after discontinuation of medication was associated with an increased risk of CTD recurrence (OR = 4.80, 95% CI: 1.83–12.61), consistent with previous reports of higher Mycoplasma infection rates in children with tics compared to healthy controls [13, 14, 15].