MAPT and Alzheimer disease: The search strategy used a combination of keywords to identify pertinent research articles, including “Alzheimer's disease,” “eye,” “retina,” “lens,” “pupil,” “cornea,” “choroid,” “eye movement,” “optic disc,” “optic nerve head,” “histopathological study,” “tau,” and “amyloid.” Additional terms and Boolean operators were used as needed to refine the search and ensure comprehensive coverage of the literature.