In tumor tissues, pathways related to aerobic energy production (e.g., aerobic respiration I [cytochrome c]) and ubiquinol biosynthesis were enriched in LN + tumor tissues, while LN- tumors were characterized by pathways associated with basic biosynthetic functions, including pyruvate fermentation to acetate and lactate II and superpathway of L-aspartate and L-asparagine biosynthesis. Here, CYCS is linked to neoplasm.