ILC2s also secrete Th2 cytokine and are dependent on the Th2 cell transcription factor GATA binding protein 3 (GATA3) but lack TCR expression.153–155 Notably, Th2 cells in the TME correlate with the progression of breast and cervical cancers.156–158 In addition, type 2 immunity, largely driven by Th2 cells, has been shown to promote tumor metastasis in breast, colorectal, and lung cancers.159–162. This evidence concerns the gene GATA3 and lung cancer.