IL6 and neoplasm: Cytokines (e.g., IL-6 and IgG) and immunomodulatory molecules produced by B cells may also affect the M1 and M2 polarization status of TAMs.198 Activated B cells can secrete chemokines, which increase the recruitment of TAMs to the tumor microenvironment and collectively influence T-cell responses, and can also promote tumor progression through degradation of the extracellular matrix and enhancement of angiogenesis in a granulocyte- and macrophage-dependent manner.199