In 2020, they published a research paper reporting that treatment with HER2-targeted CAR-M cells resulted in good tumor-killing effects in a mouse model and that it was able to transform M2 macrophages into M1 macrophages, induce an inflammatory TME, and enhance the antitumor cytotoxicity of T cells.237 Subsequent studies have shown that CAR-M cells have a significant therapeutic effect on a variety of different tumors. This evidence concerns the gene ERBB2 and neoplasm.