Studies have shown that pyroptosis induced by photocatalytic carbon dots can significantly increase the antigen-presenting capacity of macrophages, thereby triggering specific tumor immune responses and providing new insights for tumor immunotherapy.112 Furthermore, clusterin (CLU) promotes the polarization of macrophages toward the M1 phenotype by inducing mitochondrial damage and activating the type I interferon pathway, thus enhancing their antitumor capabilities.113 This mechanism further highlights the central role of organelle signaling in tumor immune responses. The gene discussed is CLU; the disease is neoplasm.