Jiao et al.220 The methylation and mRNA expression of Septin 9 (SEPT9) in different cervical tissues were detected via methylation-specific PCR and qRT‒PCR, which revealed that SEPT9 methylation promoted tumorigenesis and radioresistance in cervical cancer by targeting the HMGB1-RB axis and affected the resistance of cervical cancer to radiotherapy by mediating the ability of miR-375 to promote M2 polarization. This evidence concerns the gene HMGB1 and cervical cancer.