CTLA4 and cancer: A study by Selby et al. demonstrated that anti-CTLA-4 antibodies act through macrophages expressing Fcγ receptors.216 They demonstrated in mouse model experiments that macrophage-mediated elimination of Treg cells by ADCC is an important component of anti-CTLA-4 therapeutic activity.216 Many previous studies have demonstrated that the development of ADC drugs that target TAMs may provide a new therapeutic approach for cancer treatment.