PPARG and neoplasm: Moreover, Caspase-1 enhances the protumor function of TAMs by specifically cleaving Peroxisome proliferator-activated receptor gamma (PPAR-γ), while tumor cells counteract phagocytosis by overexpressing glutamine-fructose-6-phosphate transaminase 2 (GFPT2), thereby inhibiting macrophage mitochondrial fission.116 These studies not only underscore the importance of organelle function and signaling pathways in the interaction between macrophages and tumor cells but also reveal the potential of these pathways as therapeutic targets for cancer treatment.