M1-like macrophages inhibit tumor cell survival and metastasis in three main ways: first, antibody-dependent cell-mediated cytotoxicity (ADCC) action; second, antibody-dependent cellular phagocytosis (ADCP) action; and third, indirectly modulating immunity through proinflammatory factors; for example, M1-like macrophages can release proinflammatory factors such as IL-1β, IL-6, IL-12, IL-23, C-X-C motif chemokine ligand 9 (CXCL9), CXCL10, TNF-α and major histocompatibility complex (MHC) molecules. Here, TNF is linked to neoplasm.