It is used as a natural target for antigen delivery and acts as a bridge between the innate and adaptive immune responses, controlling tolerance and the immune response.188 IFN-γ and other cytokines secreted by DCs upon activation may promote the polarization of TAMs toward the M1 type (antitumorigenic type), and DC infiltration into tumors may also induce tumor growth and metastasis by modulating angiogenesis, host immunity, and tumor metastasis.189. Here, IFNG is linked to neoplasm.