HDAC2 and Sepsis: Furthermore, a dual inhibition strategy targeting HDAC2 and CARM1 not only suppressed inflammation, prevented from multiple organ dysfunction, but also enhanced the antimicrobial activities, which finally improved survival rate of mice with sepsis induced by cecal ligation and puncture (CLP).<h4>Conclusion</h4>Our findings reveal a novel role for HDAC2 in modulating anti-infectious immunity through NETs formation during sepsis.