HDAC2 and Sepsis: Neutrophil extracellular traps (NETs) is a major mechanism by which neutrophils resist pathogens invasion, but the mechanism of the NETs formation remain completely unclear.<h4>Objectives</h4>This study aims to elucidate the role of Histone Deacetylase 2 (HDAC2) in NETs formation and its impact on antimicrobial and anti-inflammatory activities in sepsis.<h4>Methods</h4>We employed flow cytometry, immunofluorescence and western blotting to assess NETs formation.