In contrast, in the sham-RIPC, there was no change in the urinary level of (TIMP-2) × (IGFBP7) before coronary angiography; however, following the procedure, a significant increase in urinary (TIMP-2) × (IGFBP7) was observed up to 48 hrs indicating kidney stress and a higher risk of AKI in this group after exposure to contrast media during invasive coronary angiography. This evidence concerns the gene TIMP2 and acute kidney injury.