Co-localization of SVA-N protein with Lyz of Paneth cells and Lgr5 of intestinal stem cells was observed at 12 hpi, as well as co-localization of SVA-N protein with Ki67 of proliferating cells at 20 hpi, suggesting that these Paneth and intestinal stem cells, as well as proliferating cells, may also be susceptible to infection by SVA after infection of enterocytes and enteroendocrine cells. The gene discussed is LGR5; the disease is infection.