PIEZO1 and lymphedema: Moreover, an endothelial Piezo1‐disrupted mouse strain that survives to birth revealed a postnatal lymphatic phenotype, with the mice dying shortly after birth from generalized lymphedema with pleural effusion.[6] Variation in the timing of the lethality from mid‐gestation[2] to shortly after birth[6] may reflect an experimental dependence on the embryonic timing of the activation of the endothelial promoter (i.e., Tie2) used to drive gene disruption.[9]