Interestingly, although both ischemic cardiomyopathy (ICM) and hypertrophic heart disease (HCM) involve mitochondrial dysfunction and cardiomyocyte stress-induced apoptosis, our findings reveal that Letm1 expression is selectively upregulated in ICM but remains unchanged in HCM. This evidence concerns the gene LETM1 and ischemic cardiomyopathy.