The expression of inflammatory genes, such as Stat3, Nfkbia, Fgfr1, IL6st and Notch2, was significantly reduced in Phf2 shRNA-injected 5xFAD mice (Fig. 6A, 21–40%, p < 0.05 to p < 0.01, t-test), suggesting that the elevated inflammation genes in AD can be reversed by Phf2 knockdown. This evidence concerns the gene PHF2 and Alzheimer disease.