FOXO1 and Alzheimer disease: Quantitative PCR revealed a significant reduction of most of these AD-related inflammation genes by Phf2 knockdown (Stat3: 52.1 ± 7.9%, p < 0.01, Nfkbia: 20.5 ± 1.4%, p < 0.01, Nfkb2: 26.5 ± 2.9%, Foxo1: 55.1 ± 16.4%, Tnfrsf1a: 24.8 ± 2.9%, Fgfr1: 21.3 ± 2.0%, IL6st: 17.8 ± 1.4%, Notch2: 23.1 ± 2.6%, Csf1: 36.0 ± 4.2%, all p < 0.05) (Fig. 3C).