PHF2 and Alzheimer disease: As shown in Fig. 1C, compared to control samples (‘no-pathology’), PHF2 was significantly increased in excitatory neurons (Ex) and inhibitory neurons (In) of the ‘early-pathology’ AD samples (Ex: p = 5.08E–12; In: p = 0.0097), as well as the pooled AD samples (‘early pathology’ and ‘late-pathology’) (Ex: p = 3.83E–07; In: p = 0.0198).