STAT1 and central nervous system cancer: Their study demonstrated that high STAT1 expression was significantly associated with poor overall survival (OS) in patients with renal carcinoma, low-grade glioma, and lung adenocarcinoma et al. In contrast, elevated STAT1 levels correlated with prolonged OS in high-grade serous ovarian carcinoma, oral squamous cell carcinoma, and rectal adenocarcinoma et al. Ovarian cancer (OV), the most lethal gynecologic malignancy, presents significant therapeutic challenges due to frequent late-stage diagnosis and high recurrence rates [12].