Tissue-specific prognostic discordance was observed via univariate Cox proportional hazards regression: elevated STAT1 isoform expression correlated with adverse outcomes (hazard ratio [HR] > 1) in uveal melanoma (UVM), thymoma (THYM), and pancreatic adenocarcinoma (PAAD), while demonstrating protective associations (HR < 1) in sarcoma and OV (Fig. 2C). Here, STAT1 is linked to sarcoma.