PPARG and Friedreich ataxia: Furthermore, it has been described that ALA induces mitochondrial biogenesis by increasing the SIRT1 and PGC1α expression, which have neuroprotective properties, reducing oxidative stress, inflammation and preventing cell death [85, 86].The inhibition of PPARγ using T0070907 [87, 88], avoided the beneficial effect of ALA, suggesting that PPARγ activation is at least one of the key mechanisms through which ALA ameliorates the mutant phenotype of FRDA fibroblasts.