Specifically, Macro18 showed high expression of SPP1, APOE, LPL, FABP5, and GPNMB (Fig. 2E), and thus a transcriptional phenotype similar to lipid-associated macrophages (LAMs)23 and to a previously described CNS myeloid population in stroke with a phagocytic and lipid-sensing phenotype24. The gene discussed is APOE; the disease is Stroke.