NRG1 and osteochondritis dissecans: In addition, the expression of erb-b2 receptor tyrosine kinase 4 (ERBB4) and neuregulin 1 (NRG1), proteins associated with inhibitory neurotransmitter release, were found to be significantly downregulated in the mPFC.<h4>Conclusion</h4>OD attenuates GABAergic synaptic transmission in the mPFC, which may be the neural mechanism of anxiety caused by OD.