To investigate whether the Acaa1a gene influences the developmental stages of pancreatic cancer, we crossed Acaa1a+/− mice with KPC mice (KrasLSL−G12D/+, Trp53LSL−R172H/+, Pdx1-Cre) to produce Acaa1a+/−/KPC mice, a model for pancreatic cancer. This evidence concerns the gene PDX1 and familial pancreatic carcinoma.