ACAA1 and pancreatic neoplasm: To explore the impact of FAO activity in peroxisomes on pancreatic cancer, we compared the expression of ACAA1 and peroxisomal acyl-coenzyme A oxidase (ACOX1), the key proteins involved in FAO within peroxisomes, using commercially available pancreatic cancer tissue microarrays (Supplementary Fig. 1A–C).