In various other cancer cell lines besides pancreatic cancer, including OVCAR-8 (ovarian cancer), A549 (lung cancer), SNU-449 (liver cancer), HCT-8 (colon cancer), and PC-3 (prostate cancer), ACAA1 knockdown similarly reduced basal respiration and ATP production (Supplementary Fig. 2A and B). Here, ACAA1 is linked to colonic neoplasm.