ZDHHC6 and Alzheimer disease: Compared to wild-type mice, 6-month-old 5 × FAD transgenic mice—a widely used model of AD—exhibited a significant reduction in GluA2 palmitoylation levels in the hippocampus, whereas the total protein levels of GluA2 and its primary palmitoyltransferase DHHC6 remained unaltered (Fig. 6a).