CXCR4 and neoplasm: Tumor effector memory CD8 T cells demonstrated overexpression of CCR7, IL7R, and CXCR4, which are associated with a naïve-like T cell state and inversely associated with T cell polarization and effector T cell function [33–35], as well as TXNIP, which negatively regulates T cell proliferation [36] (Supplementary Fig. S3B, Supplementary Table S5).