The dimerization of TDP‐43 is highly dynamic, and this dynamic property makes it challenging to capture a stable dimerization structure using traditional structural biology methods, such as X‐ray crystallography or nuclear magnetic resonance (NMR).[12] However, understanding the role of TDP‐43 dimerization in neurodegenerative diseases is crucial for uncovering the mechanisms underlying ALS and related disorders. Here, TARDBP is linked to neurodegenerative disease.