Interferon activates a signal transduction cascade to stimulate the induction of a wide array of ISGs with antiviral activities.[108, 109] For example, MX Dynamin Like GTPase 1 (Mx1) is an interferon‐induced dynamin‐like GTPase that antagonizes the replication of several RNA and DNA viruses.[109] Similarly, ISG15 is an interferon‐induced 15 kDa ubiquitin‐like protein that regulates the viral replication by conjugation with viral proteins.[110] An enhanced expression of ISGs provides antiviral immunity against virus infection. This evidence concerns the gene MX1 and viral infectious disease.