Regarding blood tumor burden, patients with SS showed elevated lymphocyte counts (median, 4185 vs. 1060 cells/μl; p = 0.02), CD4+ lymphocytes (median, 2170 vs. 575 cells/μl; p = 0.04), and a trend toward higher CD3+ counts (median, 1765 vs. 784 cells/μl; p = 0.065) compared to patients with eMF. The gene discussed is CD4; the disease is neoplasm.