We identified that sgRNAs targeting ATR, CHEK1, WEE1, ATR, RPA3 and RAD51 were the most depleted indicating essentiality in DLBCL cell lines (Figure 1).We did not identified a specific dependency for ABC or GCB cell lines except for APEX2 that is only essential in ABC DLBCL cell lines. This evidence concerns the gene CHEK1 and diffuse large B-cell lymphoma.