Especially in EGFR‐mutant tumours, RB1 inactivation via complex rearrangements appears to favour SCLC/LUSC transformation under growth inhibitory pressure,125 but this transformation has no significant association with EGFR mutations and is often accompanied by the down‐regulation of EGFR expression.6, 108, 126. This evidence concerns the gene RB1 and small cell lung carcinoma.