For instance, TFs such as SOX2 and NKX2‐1 are crucial in mediating the transformation of LUAD to squamous carcinoma, while epigenetic regulators like EZH2 and LSD1 influence tumour cell differentiation and proliferation by modulating histone modifications and DNA methylation.86, 87, 88, 89. The gene discussed is NKX2-1; the disease is neoplasm.