It has been demonstrated that in the presence of specific driver mutations, club cells in the mouse lung can develop into squamous cell carcinoma upon SOX2 up‐regulation (in combination with LKB1 deletion) and into LUAD upon NKX2‐1 regulation (in combination with EGFR mutation), each developing a distinct immune microenvironment corresponding to these histological types of lung cancer.58, 61. The gene discussed is SOX2; the disease is squamous cell carcinoma.