At the same time, hypoxia drives the expression of VEGF and VE‐cadherin in VM, with pathways such as EphA2/PI3K and MMP‐2/MMP‐9 coordinating ECM remodelling and channel formation, allowing cancer cells to acquire endothelial‐like traits and form vascular‐like structures, further supporting metastasis and resistance169, 170, 171 (Figure 3B). This evidence concerns the gene PIK3CA and cancer.