ACOX2 and Peroxisome biogenesis disorder-Zellweger syndrome spectrum: This does seem to be borne out by the fact that end‐stage liver disease has been described in a disorder of ABCD3, the peroxisomal THCA‐CoA importer, and some individuals with a peroxisome biogenesis disorder, while acyl‐CoA oxidase 2 deficiency tends to produce milder liver dysfunction, as do disorders of the steps beyond ACOX2.