CD274 and neoplasm: To confirm this hypothesis, we established a subcutaneous tumor implantation model using C57BL/6 mice with ST6GAL1‐NC, ST6GAL1‐KD, and ST6GAL1‐OE MC38 cell lines, followed by treatment with either PBS or a combination of anti‐PD‐L1 and cisplatin (Figure 4K).