One possible explanation of above results is that ST6GAL1 may induce an immunosuppressive phenotype, where abundant immune cells are retained in the stroma instead of penetrating into the tumor nests.[23, 24] Using CRC tissue microarrays, we confirmed that high ST6GAL1 expression is associated with reduced CD8+ T cell infiltration and increased PD‐L1 expression. This evidence concerns the gene CD274 and neoplasm.