CD274 and colorectal carcinoma: These results suggest that ST6GAL1 plays a pivotal role in the CRC TME, where low expression of ST6GAL1 may be associated with CD8+ effector T cell infiltration, tertiary lymphoid structure, and M1 macrophage polarization, thus fostering an “immune‐activated” TME that potentially improves prognosis and may enhance the sensitivity to PD‐L1 immunotherapy.