More importantly, we identified through in vivo and vitro experiments that knockdown of ST6GAL1 resulted in a dampened proliferative and metastatic ability of CRC cells, probably due to the decreased α2,6‐sialylation of PD‐L1 mediated by ST6GAL1, which downregulates the stability of PD‐L1 and leads to further ubiquitination and degradation. Here, CD274 is linked to colorectal carcinoma.