However, accumulation was also observed in non‐tumor tissues, such as the liver and lungs, consistent with previous reports.[19, 24] Given that activated CAR‐HMs may secrete pro‐inflammatory cytokines (e.g., IL‐6 and TNF‐α), their long‐term persistence in normal tissues could potentially cause off‐target effects. The gene discussed is IL6; the disease is neoplasm.