Notably, FcγRI‐CAR‐HMs retained an M1 phenotype (CD86hiCD206low) in the immunosuppressive TME and remodeled the TME to promote T cell infiltration and activation, as shown by increased expression of immunostimulatory cytokines (e.g., IL‐12p70 and TNF‐α) and chemokines (e.g., CXCL9).[55, 56, 57, 58, 59] Taken together, these in vitro and in vivo results demonstrate that FcγRI‐CAR‐HMs exert direct anti‐tumor effects and reshape the immunosuppressive TME to promote adaptive immune responses. Here, TNF is linked to neoplasm.