2007). Some chronic systemic diseases, such as hypertension and diabetes, can also impair cognitive function by reducing the regional cerebral blood supply, and the incidences of hypertension and diabetes are closely related to higher AIP (Tan et al. 2023; Yin et al. 2023). In addition, cerebral ischemic damage is aggravated by the ensuing neuroinflammatory response driven by proinflammatory cytokines (Li et al. 2017). The gene discussed is AIP; the disease is hypertensive disorder.