LIMCH1 and neoplasm: To further study the effects of MM and Scl-ab on osteoblastic cells, we quantified osteoblasts (Bglap+) and osteo-CARs (Limch1+), which are primarily located at bone surfaces [19], adipo-CARs (Cxcl12+), which are mainly found within the bone marrow near sinusoidal blood vessels [22], and MM cells (human UBC+) in the tumor microenvironment using a combination of gene expression markers and spatial location (Figs. S8A-C).