Further research within the early AD continuum also underpins the findings of ALF in cognitively asymptomatic individuals at-risk but differed in terms of defining preclinical stages of AD (e.g., asymptomatic familial AD [22, 23], cognitively asymptomatic ApoE4 carriers [20], and preclinical AD stage 1 [19]). The gene discussed is APOE; the disease is Alzheimer disease.