When NRF2 translocates into the cell nucleus and heterodimerizes with small Maf proteins, they bind to AREs to initiate the transcription of a series of antioxidant enzyme genes, including GCLC, GCLM, GSTM1, GPX4, GSR, TXN1, PRDX1, SRXN1, and NQO1 [76–80], etc. Therefore, NRF2-mediated antioxidant transcriptional regulation is critical for tumor cells to counteract oxidative stress. This evidence concerns the gene TXN and neoplasm.