Additionally, ROS-induced NF-κB [162], HIF-1α, and TGF-β [163, 164] pathways increased uPA and MMP-9 for extracellular matrix reshaping, affecting the integrity of intercellular connections in tumor cells and activating the PI3K/AKT pathway to promote tumor cell mobility [165, 166]. This evidence concerns the gene PLAU and neoplasm.