ISG15 and acute myeloid leukemia: To detail the phenotypic features of epitope-specific CD8 + T-cells in AML BM we analyzed patient scRNA+TCRαβ-seq data resolving cell clusters: naïve/central memory (SELL, LEF1, CCR7), effector/resident memory (CD69, CXCR6), effector (KLF3), TEMRA (GZMA, GZMH, PRF1, NKG7), NK-like TEMRA (FCGR3A, KIR2DL1/2 among cytolytic molecules) and interferon clusters (ISG15, MX1) (Fig. 5A, B).