NTRK1 and obesity due to melanocortin 4 receptor deficiency: The Reactome pathway analysis based on GSEA (Fig. 6F) revealed that the PBMCs of individuals with obesity mainly participated in pathways related to lipid metabolism, G Protein-Coupled Receptor (GPCR) signaling, general metabolism, GPCR downstream signaling, Receptor tyrosine kinases (RTK) signaling, RNA polymerase II transcription, generic transcription pathways, gene expression (transcription), hemostasis, and the adaptive immune system.