We found that MORC3, NUP62, CGAS, ABI3, and RPA2 were highly expressed in lean individuals, where as LMNA, ID2, CDKN1A, TENT4B, MME, and MYC were upregulated in the PBMCs of individuals with obesity (Fig. 6H). This evidence concerns the gene CGAS and obesity due to melanocortin 4 receptor deficiency.