The leading edge genes for various cancers were ABHD2, ADCY7, ADCY9, AKT3, ATP1A1, ATP2B1, CHRM2, CREB1, CREB3L2, CREBBP, EP300, F2R, GABBR1, GIPR, GLI3, GRIA1, NCOA2, NFKB1, PPARA, SSTR1, TGFB1 (Fig. 2B). The gene discussed is CREBBP; the disease is cancer.