The leading edge genes for various cancers were ABHD2, ADCY7, ADCY9, AKT3, ATP1A1, ATP2B1, CHRM2, CREB1, CREB3L2, CREBBP, EP300, F2R, GABBR1, GIPR, GLI3, GRIA1, NCOA2, NFKB1, PPARA, SSTR1, TGFB1 (Fig. 2B). The gene discussed is ADCY7; the disease is cancer.