The leading edge genes for various cancers were ABHD2, ADCY7, ADCY9, AKT3, ATP1A1, ATP2B1, CHRM2, CREB1, CREB3L2, CREBBP, EP300, F2R, GABBR1, GIPR, GLI3, GRIA1, NCOA2, NFKB1, PPARA, SSTR1, TGFB1 (Fig. 2B). The gene discussed is NCOA2; the disease is cancer.