This section demonstrates that diverse nanomedicine platforms (e.g., ZCUNH, DHA@MIL-101, Fe-THBQ/SR, and CMS) can induce tumor ferroptosis through metal ion-driven redox dysregulation (e.g., GSH depletion, GPX4 inhibition, and iron overload), which subsequently activates the cGAS-STING pathway through ferroptosis-derived DAMPs (e.g., mtDNA and dsDNA). The gene discussed is CGAS; the disease is neoplasm.